Natsushio was a destroyer of the Kagero class in the Imperial Japanese Navy. Fujinagata Shipyards built her. She was launched on 23 February 1939 and commissioned on 31 August 1940.
Before the Pacific fighting spread, she had a collision in home waters. At 1800 on 23 June 1941, in the Bungo Channel, she struck the destroyers Kuroshio and Minegumo.
Sumitaka Nagai became her captain on 20 October 1941. When Japanese aircraft struck Pearl Harbor, she was serving in Destroyer Division 15, under Destroyer Squadron 2 of the Second Fleet. From Palau she had gone out to screen the carrier Ryūjō and the minelayer Yaeyama for the landings in the southern Philippines.
In January 1942 she stayed with the push into the Netherlands East Indies. Her work was escort duty for the forces put ashore at Menado, Kendari, and Ambon.
The move on Makassar ran through 8 and 9 February 1942. On 9 February the United States submarine S-37 torpedoed her south of the port. She sank about 22 miles (35 kilometers) off Makassar, at 5°10′ south, 119°24′ east. Ten of the crew were killed. Kuroshio, a sister ship, took off the survivors.
The navy removed her from its list on 28 February 1942. She was the first Japanese destroyer an American submarine sank in the war, and the first of the Kagero class to be lost.