USS Hudson (DD-475) was a Fletcher-class destroyer of the United States Navy, the second ship to carry the name of Captain William L. Hudson, whose life spanned 1794 to 1862.
She was launched on 3 June 1942. Mrs. Henry H. Hough, wife of retired Admiral Henry H. Hough, sponsored the ship. Hudson entered commission on 13 April 1943, and Richard R. Pratt became her commanding officer that day.
Hudson remained in service through the Second World War and survived it. Her wartime duty was marked by nine battle stars.
After the war she was prepared for retirement at the Puget Sound Navy Yard in Bremerton, Washington. She sailed for San Diego on 15 March 1946, was decommissioned on 31 May, and joined the reserve fleet there. In January 1947 she was moved to Mare Island Naval Shipyard in California and laid up. Her name was stricken on 1 December 1972. On 27 November 1973 she was sold for scrap and afterward dismantled.