USS Isherwood (DD-520) was a Fletcher-class destroyer, the second ship in the United States Navy to honor Rear Admiral Benjamin F. Isherwood, who lived from 1822 to 1915. Bethlehem Shipbuilding launched her at Staten Island, New York, on 24 November 1942. Mrs. A. J. Kerwin, a granddaughter of the admiral, sponsored the ship. The Navy commissioned Isherwood on 12 April 1943 at the New York Navy Yard, and R. E. Gadrow took command that day.
Her early weeks were spent working the ship up. Through April and May the crew trained in Casco Bay on the coast of Maine and in Cuban waters off Guantanamo Bay. For the two months after that she ran with a patrol and escort group based at the naval station at Argentia, Newfoundland.
On 5 August 1943 she sailed for England in company with the liner Queen Mary, then serving as a troopship. She entered Scapa Flow on 19 August and joined in operations with the British Home Fleet, among them a sweep that reached toward Spitsbergen in search of the German battleship Tirpitz. She put to sea again on 14 September, sailed with a convoy, and arrived at Boston on 29 September 1943.
Orders then took her to the Pacific. She left Boston on 14 November for San Francisco and continued from there to Pearl Harbor. On 11 December she sailed to report to Task Force 94 in the Aleutians, and that duty with the force occupied the next eight months. Isherwood survived the war. On 8 October 1961 the United States loaned her to Peru.