USS Sigsbee (DD-502) was a Fletcher-class destroyer of the United States Navy. The name honored Charles D. Sigsbee, a rear admiral who lived from 1845 to 1923. Her keel was laid on 22 July 1942 at Federal Shipbuilding and Dry Dock Company in Kearny, New Jersey. She entered the water on 7 December 1942, sponsored by Mrs. A. O. Fischer, and joined the fleet on 23 January 1943 with B. V. Russell in command.
Fitting out lasted about three weeks. She then sailed to Casco Bay, Maine, and spent ten days drilling with her guns and torpedoes before going on to Guantanamo Bay, Cuba, to finish shakedown. After those trials she went back to the Brooklyn Navy Yard in New York City for overhaul. When the yard work ended, she took the light cruiser Birmingham (CL-62) south to Norfolk.
On 4 April 1943 she escorted two tankers to Casco Bay and came back. Her next passage was with the carrier Independence (CV-22) and the destroyer Guest (DD-472) to Trinidad in the British West Indies, where Independence exercised her air group. After returning to Norfolk, Sigsbee refueled. With Guest and Earle (DD-635) she then escorted the carrier Lexington (CV-16) to Trinidad, and the ships arrived on 16 May.
On 8 June she left that formation and steamed to New York by herself. From New York she continued operating. Sigsbee survived the war. On 31 July 1975 the hull was sold to be broken up.