USS Hughes (DD-410) was a Sims-class destroyer of the United States Navy. Donald J. Ramsay took command of the ship on 21 September 1939.
On 4 June 1942, during the Battle of Midway, Hughes served in the screen of the carrier Yorktown. She remained afloat through that day. Hughes survived the war and was still afloat at the surrender. After the Bikini tests, she was sunk as a target off the Washington coast on 16 October 1948.
