USS O'Brien (DD-415) was a Sims-class destroyer of the United States Navy. The Boston Navy Yard built her. She was launched on 20 October 1939 and commissioned on 2 March 1940.
On 15 September 1942, southeast of Guadalcanal, one torpedo from the submarine I-19 hit her in the bow.
That torpedo was part of the same spread that struck the carrier Wasp and the battleship North Carolina. O'Brien stayed afloat.
She started for Pearl Harbor with the damaged bow. On 19 October 1942, still on the way, the hull broke up and she foundered. The whole crew got off.
The ship that went down on that passage was the Sims-class destroyer DD-415. A later United States Navy destroyer also carried the name O'Brien.
