USS Wickes (DD-578) was a Fletcher-class destroyer. The Navy gave her the name of Captain Lambert Wickes, an officer of the Continental Navy (1735–1777); an earlier hull had already carried that name.
Consolidated Steel Corporation laid the keel at Orange, Texas, on 15 April 1942. Launch day was 13 September 1942, and the sponsor was Miss Catherine Young Wickes, great-great-grandniece of the captain for whom the ship was named. She entered commission on 16 June 1943 with William Y. Allen in command.
On 13 July she put to sea from New Orleans, Louisiana, bound for Cuba, and made Guantanamo Bay on the third day. Trials there continued until 11 August. She then steamed to Charleston, South Carolina, and began the availability that follows shakedown. Through the fall, from 1 September until 6 November, her training track stretched between Trinidad in the British West Indies and Casco Bay in Maine, and between Norfolk, Virginia, and Naval Station Argentia, Newfoundland. Brief docking at Boston and at Norfolk interrupted the drills.
She sailed from Boston Navy Yard on 6 November alongside Cabot (CVL-28), a small aircraft carrier, and the destroyer Bell (DD-587), all bound for the Canal Zone, and she was then moving through the Panama Canal. William Y. Allen, who had commanded her from commissioning, was relieved on 25 July 1944. She survived the war. On 8 April 1974 the ship was sunk as a target.